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Start with what the screen is for. If you edit photos, grade video, work in 3D or write code all day, the extra pixels of a 5K panel keep text and fine detail razor-sharp, and 218 PPI matches the native 2x scaling that macOS expects. If your work mixes high-detail creative with gaming, a 4K display paired with a strong colour gamut and a higher refresh rate is often the better-balanced buy.
Then check the panel and the plumbing. IPS Black lifts contrast over standard IPS, OLED delivers the deepest blacks, and Mini-LED drives the brightest HDR. For accuracy, look for 98%+ DCI-P3, wide AdobeRGB coverage and a rated Delta E under 2. Finally, confirm your graphics card has the VRAM and the DisplayPort 2.1, HDMI 2.1 or USB-C bandwidth to run the resolution and refresh rate you are paying for.