DDR5 is electrically and physically incompatible with DDR4 even when a processor family is sold with motherboard choices for both.
The board memory list and processor controller define supported capacity and speeds. A BIOS update can improve compatibility but does not turn DDR4 slots into DDR5.
XMP and EXPO store tested overclock settings for compatible firmware. The rated profile is not guaranteed on every CPU, board or multi-kit combination.
Data rate and latency timings jointly influence performance, with workload response varying. Stable settings matter more than the largest number on the package.
Tall heat spreaders can collide with large air coolers or compact cases. Check DIMM clearance after the CPU cooler fan is positioned.
Adding another nominally identical kit can change memory chips and controller load. A validated 64GB kit is safer when that total capacity is already expected.