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DDR4 has shifted from the default choice to the budget and upgrade tier, because most new processor platforms now use DDR5. It still matters for a huge installed base: AMD's AM4 socket and many Intel LGA1700 boards run DDR4, so a memory top-up is often the cheapest way to extend the life of a system you already own.
The two standards are not interchangeable. DDR4 and DDR5 use different slot keying, pin counts and voltages, so a module only fits the generation its motherboard was designed for. Before buying, confirm which memory type your board supports, its maximum rated speed, and how many slots you have to fill.