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ASUS publishes the Strix as 332 x 147.3 x 64mm across 3.2 slots, which puts it firmly in mid-tower territory and rules out most compact chassis. That size is the main thing you are deciding on, because the frame rate difference against a smaller card on the same GPU sits in low single digits.
What follows covers where ROG sits in the range, what the extra heatsink volume actually delivers, how to make room for it, and what the rendering feature set on a 70-class Blackwell card is worth.